Sylvia Will Given Question & Answer Guide (With Explanation)

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Original Question

Sylvia will be given induction immunosuppressants at the time of the transplant, and continue to take maintenance immunosuppressants the rest of her life. This will prevent her body from rejecting the transplanted heart in the future. Examine Table 1. Table 1. Maintenance immunosuppressants, medication, and their action on lymphocytes. Class of Immunosuppressant Medication Action on Lymphocytes Calcineurin inhibitors tacrolimus, cyclosporine · Reduces release of cytokine (interleukin-2) from T cells · Reduces T cell proliferation Antiproliferative agents mycophenolate mofetil, mycophenolate sodium, azathioprine, cyclophosphamide · Reduces T cell and B cell proliferation · Reduces antibody formation · Reduces cell-mediated immune response mTOR (mammalian target of rapamycin) inhibitors sirolimus, everolimus · Reduces T cell and B cell proliferation Corticosteroids / glucocorticosteroids prednisone · Reduces cytokine production · Reduces T cells and B cells There are multiple ways that immunosuppressant drugs work to reduce activity of the immune system. Which of the following is NOT an effect of immunosuppressant drugs on lymphocytes? a. reduced lymphocyte proliferation b. reduced cytokines c. reduced antibodies d. reduced self-antigens

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