Rephrase Pathophysiologically Axonal Question & Answer Guide (With Explanation)

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Use appropriate theories and support your answer with clear reasoning.

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Original Question

Rephrase: Pathophysiologically, axonal damage can be seen only with an electron microscope and involves numerous axons, either alone or in conjunction with actual tissue tears. Advanced imaging techniques using MRI are assisting to define areas and extent of injury. Areas where axons and small blood vessels are torn appear as small hemorrhages (Fig. 18.8), located particularly in the parasagittal white matter near the cerebral cortex, corpus callosum, and brainstem and at the superior cerebellar peduncle.6 More damaged axons are visible 12 hours to several days after the initial injury. The severity of DAI correlates with the amount of shearing force. DAI is not associated with intracranial hypertension immediately after injury. However, acute brain swelling from increased intravascular blood flow within the brain, loss of cerebrovascular autoregulation, vasodilation, and increased cerebral blood volume is often seen and can result in death. DAI may induce long-term neurodegenerative processes, with progressive axonal pathology that may continue for years after injury and may play a role in the development of chronic traumatic encephalopathy and Alzheimer disease-like pathologic changes.7

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