Keen Mountaineer Moved Assignment Help: How to Answer This Question
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Original Question
A keen mountaineer, moved from sea level to a city at an altitude of 3,500 meters, and has been living there for the past five years. At this elevation, the partial pressure of oxygen is approximate 1/3 of sea level. Lately, the mountaineer has been experiencing fatigue and shortness of breath and was diagnosed with chronic mountain sickness (CMS). This person has also developed sleep-disordered breathing (SDB), characterised by intermittent apnoea during sleep. a) Consider the graph below that represents three difference versions of the Oxyhaemoglobin Dissociation curve. “A” and “B” label two of the curves. i) What do “A” and “B” represent? (0.5 marks) ii) Identify which of the two curves would you anticipate would be relevant during sleep in this person? Explain your reasonings. (1 mark) b) One of the features of sleep-disordered breathing is elevated sympathetic nerve activity (SNA). i) Describe the impact of this elevated SNA on systemic arterial pressure, and the impact of this increase in SNA on the existing pulmonary hypertension. (3 marks) ii) Chronic low level of inflammation is often found in sleep apnoea patients and is reflected by measurements of elevated cytokines in the blood. Explain how elevated sympathetic nerve activity would affect cytokine release. (0.5 marks) Image transcription text 1.0 A 0.8 0.6 Observed hemoglobin- Y (fractional saturation) binding curve 0.4 0.2 B 0.0 0 50 100 150 200 po2 (torr)
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