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Rephrase and shorten this “Hormones released from the gastrointestinal (GI) tract play a role in insulin resistance, beta-cell function, and diabetes.98 Ghrelin is a peptide produced in the stomach and pancreatic islets that regulates food intake, energy balance, and hormonal secretion. Decreased levels of circulating ghrelin have been associated with insulin resistance and increased fasting insulin levels. Its use as a potential treatment for type 2 DM is being investigated.111 The incretins are a class of peptides that are released from the GI tract in response to food intake and function to increase synthesis and secretion of insulin and beta cell proliferation and regeneration, and protection against beta-cell damage. The most studied incretin is glucagon-like peptide 1 (GLP-1), and studies have demonstrated that beta-cell responsiveness to GLP-1 is reduced both in prediabetes and in type 2 diabetes

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