How to Answer Conduct Cohort Study Questions (Complete Guide)

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Original Question

You conduct a cohort study and find that the risk of death is 963 per 100,000 person years among those who have gene mutation Z (i.e., the exposed), whereas the risk of death is 127 per 100,000 person years among those who do not have gene mutation Z (i.e., the unexposed). The population from which the cohort was drawn has 800,000 people, of whom 400,000 have gene mutation Z. What is the risk ratio (relative risk) of mortality for those who have gene mutation Z as compared to those who do not have gene mutation Z? How much of the risk of death is attributable to gene mutation Z (i.e., what is the attributable risk)? Use 100,000 as your multiplier and remember to use the correct units How many deaths occur each year in the population, given the incidence rates and the distribution of people in the exposed and unexposed groups, described above? Please show your work for the calculation of the number of deaths among the unexposed group, the exposed group, and the total. How many deaths would occur each year in the population, if both the exposed and unexposed groups experienced the mortality rates of those in the unexposed group? What is the mortality attributable to being in the exposed group in the population?

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