How to Answer Class Mate Post Questions (Complete Guide)

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Original Question

class mate post this about osteoarthritis. give a nice feedback and add your contributuion to the post: For this week’s discussion, explore the pathophysiological mechanisms underlying osteoarthritis. Consider the following questions to guide your response: Discuss the role of mechanical stress, inflammation, and cartilage degradation in the progression of osteoarthritis. Osteoarthritis is a common disease of the joints that results from aging. “OA is characterized by pathologic changes in cartilage, bone, synovium, ligament, muscle, and periarticular fat. These changes lead to joint dysfunction, pain, stiffness, functional limitation, and loss of activities, such as walking for exercise” (Rogers, 2022). While it is thought that OA is an inflammatory disease, it is actually more of a degenerative disease. OA occurs because there is a disruption in the chondrocytes. The chondrocytes are responsible for making new cartilage, however, in OA, the chondrocytes either don’t make the cartilage fast enough or the ECM is destroyed. The role of mechanical stress, inflammation and cartilage degradation in the progression of OA is that mechanical stress weakens the cartilage and can then cause inflammation. Inflammation then causes the joint to become still and can fill with fluid. Cartilage degradation occurs and causes pain with movement. When the pain occurs, this causes the person to not want to move to relieve the pain. How does aging contribute to the development of OA? What othe

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