Get Answer: Year Male With Question Guide

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This question relates to year male with and requires a structured academic response.

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Break the problem into smaller parts and analyze each logically.

Key Explanation

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Original Question

A 60-year-old male with a history of chronic back pain secondary to lumbar spinal stenosis has been on long-term opioid therapy with oxycodone. He presents to the clinic complaining of severe constipation that has not responded to over-the-counter laxatives, including bulk-forming agents, osmotic laxatives, and stool softeners. His physical examination is unremarkable except for distended abdomen with palpable stool. The PA decides to prescribe naloxegol to manage his opioid-induced constipation (OIC). What is the mechanism of action of naloxegol that makes it suitable for treating OIC in this patient? Group of answer choices Naloxegol is a mu-opioid receptor antagonist that counteracts opioid effects on the gastrointestinal tract without affecting central pain relief. Naloxegol functions by softening the stool and increasing its bulk to ease bowel movements. Naloxegol increases the secretion of water and electrolytes into the intestines, which softens the stool and promotes bowel movements. Naloxegol works by directly stimulating the bowel muscles to enhance peristalsis.

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