Get Answer: Salbutamol Direct Acting Question Guide
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Original Question
Salbutamol is a direct acting sympathomimetic agent which mainly has β-adrenergic activity and a high degree of selectivity for β2-adrenoceptors. As a predominantly β2-adrenoceptor stimulant, salbutamol’s bronchodilating action is relatively more prominent than its cardiac effects. Salbutamol is chemically related to adrenaline, noradrenaline and isoprenaline, but it has a longer duration of action than these compounds. This is possibly due to its resistance to catechol-O-methyl transferase (COMT), an inactivating enzyme which occurs in association with sympathetic receptors. The β-sympathetic agonists act primarily through activation of adenylate cyclase which catalyses the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP). Cyclic AMP mediates the effects of the β-agonists on sympathetic receptors. Increased cAMP concentrations also inhibit release of mediators of immediate hypersensitivity from mast cells, as well as relaxing bronchial smooth muscle. Stimulation of β2-receptors causes relaxation of the smooth muscle of the bronchi, uterus and blood vessels, decreases the duration of skeletal muscle contraction and increases glycolysis and glycogenolysis. Airomir contains the sulfate salt of salbutamol, which has been shown to be clinically equivalent to salbutamol base when administered in equivalent doses by metered dose inhaler. write in simplest form
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