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reword this … These symptoms are classic for a serious condition called congenital adrenal hyperplasia (CAH), more specifically 21-hydroxylase deficiency. In simple terms, CAH is a hormonal disorder babies are born with. Their adrenal glands, which sit above the kidneys, can’t make enough of the hormones that help with stress (cortisol) and salt balance (aldosterone). Instead, they produce too many male hormones (androgens), which can cause a baby girl to be born with masculinized genitalia (Nath, 2022; Speiser et al., 2022). This happens because a genetic mutation blocks the 21-hydroxylase enzyme, disrupting normal hormone pathways. Since cortisol and aldosterone aren’t being made, the body compensates by making more androgens. If not caught early, the loss of salt and water can become life-threatening, as seen in this baby’s emergency visit.4

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