Get Answer: Part Critical Summary Question Guide
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Original Question
Part 3: Critical Summary of Article #3 (84 points) Carefully read Article #3: Rohmann, J.L., Rist, P.M., Buring, J.E., and Kurth, T. (2020). Migraine, headache, and mortality in women: a cohort study. The Journal of Headache and Pain 21(27), https://doi.org/10.1186/s10194-020-01091 What were the three major classifications of the exposure variable of this study? (3 points) How was data on the exposure variable ascertained? In other words, how did they know who had one type of exposure or another and who remained unexposed? (3 points) Was there a possibility that the exposure could have been misclassified? In other words, could any of the unexposed really have been exposed? Could those with an exposure really have been unexposed? Finally, could women with one classification of the exposure have really had a different one? Why is misclassification of the exposure possible or not possible? (4 points) If misclassification of the exposure did occur, was this likely to have been differential (related to one of the outcomes) or non-differential (independent of the outcomes)? Which (differential versus non-differential misclassification) would have been more serious? (2 points) List any potential confounders including in the analyses of this study. (9 points) Which of the three ways of preventing or limiting confounding was applied to the design of this study? Be careful. This is the observational study. (1 point) Which of the two ways of controlling for confounding in the analyses was applied to this study? (1 point) Look at Table 2, which displays the main results. Cite any statistically significant associations between any of the two major exposure categories and any of the four outcomes in the fully adjusted multivariable model. If/when doing so, be sure to list the specific exposure category, specific outcome, hazard ratio (similar to a relative risk) and confidence interval. If you find no statistically significant associations say so. (2 points) In Table 3, a closer look is taken of the exposure variable, by subdividing it further into five groups, and then checking on the possible associations between each of those subgroups and each of the outcomes. What were the five subgroups, including the unexposed group? (5 points) What is the aura part of “migraine with aura”? If necessary, look it up. Be sure to define this in the context of migraine headache, not in a supernatural context. (2 points) Cite any statistically significant associations between any category of the exposure and any of the outcomes in Table 3 in the fully adjusted multivariable model. If/when doing so, be sure to list the specific exposure category, specific outcome, hazard ratio (similar to a relative risk) and confidence interval. If you find no statistically significant associations say so. (2 points) Was it likely that participants with one outcome could have been misclassified as experiencing a different outcome? Why is misclassification of the outcome likely or unlikely? (4 points) What were the three major classifications of the exposure variable of this study? (3 points) How was data on the exposure variable ascertained? In other words, how did they know who had one type of exposure or another and who remained unexposed? (3 points) Was there a possibility that the exposure could have been misclassified? In other words, could any of the unexposed really have been exposed? Could those with an exposure really have been unexposed? Finally, could women with one classification of the exposure have really had a different one? Why is misclassification of the exposure possible or not possible? (4 points) If misclassification of the exposure did occur, was this likely to have been differential (related to one of the outcomes) or non-differential (independent of the outcomes)? Which (differential versus non-differential misclassification) would have been more serious? (2 points) List any potential confounders including in the analyses of this study. (9 points) Which of the three ways of preventing or limiting confounding was applied to the design of this study? Be careful. This is the observational study. (1 point) Which of the two ways of controlling for confounding in the analyses was applied to this study? (1 point) Look at Table 2, which displays the main results. Cite any statistically significant associations between any of the two major exposure categories and any of the four outcomes in the fully adjusted multivariable model. If/when doing so, be sure to list the specific exposure category, specific outcome, hazard ratio (similar to a relative risk) and confidence interval. If you find no statistically significant associations say so. (2 points) In Table 3, a closer look is taken of the exposure variable, by subdividing it further into five groups, and then checking on the possible associations between each of those subgroups and each of the outcomes. What were the five subgroups, including the unexposed group? (5 points) What is the aura part of “migraine with aura”? If necessary, look it up. Be sure to define this in the context of migraine headache, not in a supernatural context. (2 points) Cite any statistically significant associations between any category of the exposure and any of the outcomes in Table 3 in the fully adjusted multivariable model. If/when doing so, be sure to list the specific exposure category, specific outcome, hazard ratio (similar to a relative risk) and confidence interval. If you find no statistically significant associations say so. (2 points) Look at Table 4. What is that table displaying that is different from the other tables? What is the objective of the analyses in this table? (2 points)
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