Get Answer: Buspirone Buspar Anxiolytic Question Guide
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Original Question
Buspirone (BuSpar) is an anxiolytic drug that differs significantly from the benzodiazepines. Most notably, buspirone is not a central nervous system (CNS) depressant. For treatment of anxiety, buspirone is as effective as the benzodiazepines and has two distinct advantages: it has no abuse potential and does not intensify the effects of CNS depressants (benzodiazepines, alcohol, and barbiturates). Its major disadvantage is that anxiolytic effects develop slowly: initial responses take a week to appear, and several more weeks must pass before responses peak. Because therapeutic effects are delayed, buspirone is not suitable for PRN use or for patients who need immediate relief. Buspirone has no abuse potential and thus may be especially appropriate for patients known to abuse alcohol or other drugs. Because it lacks depressant properties, buspirone is an attractive alternative to benzodiazepines in patients who require long-term therapy but cannot tolerate benzodiazepine-induced sedation and psychomotor slowing. Buspirone is labeled only for short-term treatment of anxiety. However, the drug has been taken for as long as a year with no reduction in benefit. Buspirone does not display cross-dependence with benzodiazepines. Hence when patients are switched from a benzodiazepine to buspirone, the benzodiazepine must be tapered slowly. Furthermore, because the effects of buspirone are delayed, buspirone should be initiated 2 to 4 weeks before beginning benzodiazepine withdrawal.
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