Explain System That Question & Answer Guide (With Explanation)
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Original Question
explain:In the system that the ACCP has adopted, the strength of any recommendation depends on the following two factors: the tradeoff between the benefits and the risks and burdens; and the quality of the evidence regarding treatment effect. We grade the tradeoff between the benefits, and the risks and burdens into the following two categories; category 1, in which the tradeoff is clear enough that most patients, despite differences in values, would make the same choice, leading to a strong recommendation; and category 2, in which the tradeoff is less clear, and individual patient values will likely lead to different choices, leading to a weak recommendation. We grade methodological quality in terms of the following three categories: randomized trials that show consistent results, or observational studies with very strong treatment effects; randomized trials with limitations, or observational studies with exceptional strengths; and observational studies without exceptional strengths and case series. The framework summarized in Table 2 generates recommendations from the very strong (benefit/risk tradeoff unequivocal, high-quality evidence, grade 1A) to the very weak (benefit/risk questionable, low-quality evidence, grade 2C). Whatever the grade of the recommendation, clinicians must use their judgment, considering both local and individual patient circumstances, and patient values, in making individual decisions.
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