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expaln this in simple english: Additionally, the Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension trial demonstrated a significant reduction (20%) in combined cardiovascular events in patients treated with a combination of an ACEI plus CCB (benazepril + amlodipine) compared with patients treated with an ACEI plus a thiazide diuretic (benazepril + hydrochlorothiazide) (Jamerson et al., 2008). Furthermore, the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial study demonstrated that combined ACEI and ARB therapy did not prevent cardiovascular events more than monotherapy. In fact, it showed that renal outcomes were worsened by this combination and higher risk of adverse events (Yusuf et al., 2008). Therefore, ACEIs and ARBs should not be used in combination.

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