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Reply to your professors post in 100-150 words and include one reference. When discussing levels of evidence, it is generally accepted that there is a hierarchy with how the research was performed to rate the evidence gained at a higher level of credibility and rigor (Helbig, 2022). As the quality of the research design increases, so does the quality of the evidence obtained. The base of the pyramid of hierarchy begins with expert opinions, moving to case control trials, cohort studies, followed by randomized-controlled trials (often referred to as the gold standard of research studies). Beyond RCTs are the article synopses, evidence synthesis, and then systematic reviews and meta-analysis (Ingham-Broomfield, 2016). The levels of evidence will greatly influence the probability of practice change if a higher level of evidence is utilized to provide research backing the change. The higher the level of evidence the more credible it is because the research involves larger samples utilizing design strategies that will reduce the likelihood of research bias (Bartzak, 2021). A systematic review, sometimes referred to as a meta-analysis, is a review of several randomized controlled trials (RCT) that provides an interpretation of the high level of evidence presented in the trials that often displays the effectiveness of new or improved healthcare interventions (Helbig, 2022). A practice change that could result from this level of evidence would include the effects of low-dose aspirin on obstetrical outcomes. A meta-analysis study was conducted on 47 placebo-controlled RCTs with a total of 59,124 participants reporting the impact of low-dose aspirin on pregnancy outcome (Lin, et al., 2024). References Bartzak, P. J. (2021). Creating a Nursing Procedure: When Evidence-Based Practice Doesn’t Fill in All the Blanks. MEDSURG Nursing, 30(1), 59-60. https://doi.org/10.62116/msj.2021.30.1.59 Helbig, J. (2022). History and Process of Nursing Research, Evidence-Based Nursing Practice, and Quantitative and Qualitative Research Process. In Grand Canyon University’s, Nursing Research: Understanding Methods for Best Practice (pp 7-46). Ingham-Broomfield, R. (2016). A nurses’ guide to the hierarchy of research designs and evidence. Australian Journal of Advanced Nursing, 33(3), 38-43. https://doi.org/10.37464/2016.333.1554 Lin, X., Yong, J., Gan, M., Tang, S., & Du, J. (2024). Impact of low-dose aspirin exposure on obstetrical outcomes: a meta-analysis. JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY, 45(1). https://doi.org/10.1080/0167482X.2024.2344079

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