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please simplify this….Interstitial cystitis (IC), and related conditions such as bladder pain syndrome (BPS), are a family of inflammatory conditions affecting the bladder. There is no widely accepted nomenclature for the disorder, with the umbrella term IC/BPS encompassing conditions characterized by painful, hypersensitive bladder symptoms, including urinary frequency /urgency and nocturia [67]. IC/BPS can be divided into two distinct subtypes: Hunner type (HIC), which features characteristic lesions, and BPS, where lesions are absent (Table 2). Several other types of IC/BPS can occur, including hemorrhagic cystitis and ketamine-induced cystitis, but they are not covered in this review [68,69]. Definitions of IC/BPS used in this manuscript are reviewed in Table 2. It is important to note that these definitions are not universally accepted, which may impede research into the incidence and prevalence of these conditions. Table 2. Definitions of IC/BPS and subtypes. Historically, IC/BPS was considered to be a rare condition that primarily affects females. Current evidence suggests that IC/BPS may not be as rare as previously thought as IC/BPS frequently goes undiagnosed. In 2011, the Research and Development Interstitial Cystitis Epidemiology (RICE) study estimated that 6.5% of women in the United States met a high sensitivity definition for IC/BPS, though less than 10% of these women reported an official diagnosis [70]. Further, between 1.9% and 4.2% of men screened in the RICE study met symptom criteria [71]. More research, employing definitions with both high sensitivi

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