Angiotensin Type Receptor Explained for Students (Easy Guide)

Students often encounter this when studying fundamental concepts.

What This Question Is About

This question relates to angiotensin type receptor and requires a structured academic response.

How to Approach This Question

Structure your response with introduction, analysis, and conclusion.

Key Explanation

This topic involves angiotensin type receptor. A strong answer should include explanation, application, and examples.

Original Question

Angiotensin II type 1 receptor (AT1) blocker losartan is a competitive antagonist at AT1 receptors, with 10000 fold selectivity for AT1 over AT2. While AT1 receptors are primarily involved in renin-angiotensin-aldosterone system, activation of AT2 receptors promotes vasodilation. Losartan is a hydrophilic weak acid which is metabolised by the CYP2C9 liver enzyme to produce an active metabolite E3174, and E3174 is more potent than Losartan. Although Losartan has a half life of ~2 hours, E3174 has a half life estimated at 6-9 hours. Based on this information about losartan, which of the following statements is MOST CORRECT? (3 marks/3.5 minutes) Group of answer choices Losartan will need to be administered very frequently to maintain control of blood pressure, given its half life of 2 hours Losartan effects on vascular AT2 receptors contribute to losartan effects in the treatment of hypertension Consumption of fluids that can make the urine more acidic, like cranberry juice, will prolong the half life of Losartan Taking another drug that is an inhibitor of CYP2C9 activity would increase the ability of Losartan to reduce blood pressure

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