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Document Related Documents Related Questions • Preload = the volume of blood in the heart at the end of ventricular diastole (relaxation) • Preload factors = affect cardiac output before contraction • Involves the under/over filling of the chambers of the heart Essential Heart Physiology: Preload • Frank-Starling Law of the Heart • Describe the relationship between preload and contractility of the heart • Simply states: if the heart receive a increased volume stretching the ventricles during ventricular diastole (preload) the heart will respond by contracting more forcefully (increased contractility) • However, physiological limits exist: • If excessive preload volume overwhelms the weakened ventricle, then CO decreases causing heart failure Essential Heart Physiology: Afterload • Afterload = the amount of arterial resistance that the ventricle must overcome for ejection of blood • The greater the systemic arterial vascular resistance, the greater the afterload against the left ventricle • Most commonly, afterload describes the resistance exerted by the pressure within the aorta against the left ventricle. • BUT, some condition occur because of pulmonary resistance creates high afterload for the right ventricle View full document

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