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Respond to the above classmate post by Kelsey. Reference Stahl et al 2021 with in-text citation. As stated by Stahl et al. (2021), weight gain and sedation are uncommon with Lamotrigine, but the most important side effect to watch for and report is a rash. While 10% of patients might experience a benign rash, Stevens-Johnson Syndrome (SJS) is a life-threatening emergency that presents as a rash and can be a side effect of this medication. Another life-threatening emergency that can result from taking this medication is Toxic Epidermal Necrolysis (TEN), which is a worse form of SJS where more than 30% of the body’s surface area is involved. Symptoms that should be reported immediately when concerned with SJS include flu-like symptoms such as body aches, fever, and fatigue, as well as any new rash observed on the body. Yao et al. (2025) describe the typical lesions of SJS as widespread, painful macules and lesions with central blistering, leading to extensive epidermal detachment. Risk factors for SJS include taking certain medications, such as anticonvulsants like Lamotrigine, having a weakened immune system, age, family history of this reaction, widespread infection, and specific genetic variations such as HLA haplotypes. Significant drug-drug interactions include: Valproic acid: Valproic acid will decrease the clearance of Lamotrigine, necessitating a halving of the lamotrigine dose.
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