Rephrase Treatment Nephrogenic Question & Answer Guide (With Explanation)

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Original Question

rephrase: Treatment for nephrogenic DI is based on the extent of the ADH deficiency and on the individual’s age, endocrine and cardiovascular status, and lifestyle. Some individuals require ADH replacement, but fluid replacement using oral or intravenous routes is usually adequate. ADH replacement therapy for symptomatic central or neurogenic diabetes insipidus includes intravascular or, more commonly, oral or intranasal administration of the synthetic vasopressin analog DDAVP (desmopressin).15 Management of nephrogenic DI requires treatment of any reversible underlying disorders, discontinuation of etiologic medications, and correction of associated electrolyte disorders. Surprisingly, thiazide diuretics may improve renal tubular salt and water retention in individuals with moderate nephrogenic DI. Drugs that potentiate the action of otherwise insufficient amounts of endogenous ADH, such as chlorpropamide, carbamazepine, and clofibrate, may be used in individuals with incomplete ADH deficiency. New treatments aimed at reversing aquaporin-2 dysfunction are being developed.16

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