Respond Your Friends Explained for Students (Easy Guide)

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Focus on explaining concepts clearly and supporting them with examples.

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Original Question

respond to your friends note in class, give a noce feedback and add to her post in simple english: Compare and contrast the pathophysiological mechanisms underlying AKI and CKD. Highlight how the onset, progression, and systemic effects differ between these two conditions. Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated with high mortality rates. The primary causes of AKI include ischemia, hypoxia or nephrotoxicity (Patschan, 2015). ONSET AKI is currently defined as a rapid decline in the glomerular filtration rate (GFR) resulting in retention of nitrogenous wastes, primarily creatinine and blood urea nitrogen (Basile, 2012). PROGRESSION The rapidity of this decline may occur over a course of hours to months, but typically occurs over the course of hours to days vs CKD where the kidneys gradually lose function over time. Chronic kidney disease (CKD) is characterized by ONSET the presence of kidney damage or an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m², persisting for 3 months or more. PROGRESSION CKD involves a progressive loss of kidney function, often leading to the need for dialysis or transplant and is classified into 6 stages of progression (Vaidya, 2024). SYSTEMIC EFFECTS The CRIC study showed that CKD progression was correlated with cognitive decline, cardiovascular mortality, left ventricular hypertrophy, coronary artery calcification, and clinical depression. (Vaidya, 2024). As for AKI, th

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