Simplify Paragraph Hyperandrogenism Assignment Help: How to Answer This Question

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Original Question

simplify in one paragraph:Hyperandrogenism is a multifactorial PCOS pathology influenced by a combination of environmental and heritable elements. Hyperandrogenism can result from an imbalance in the hypothalamus-pituitary-ovarian axis signaling process, leading to excess secretion of insulin and luteinizing hormone [18]. Another cause can be theca cells’ intrinsic dysfunction or diminished levels of cortisol that stimulate negative feedback on the hypothalamic-pituitary axis and elevate the synthesis of the hypothalamic adrenocorticotropic hormone after adrenal steroidogenesis stimulation, a leading factor in adrenal hyperandrogenism [19,20,21].Insulin is primarily responsible for glucose homeostasis and lipogenesis. Women with PCOS have intrinsic insulin resistance at a prevalence of 12-60% regardless of the degree of obesity or the level of androgens [28]. Insulin resistance is defined as a pathological condition characterized by decreased responsiveness or sensitivity to the metabolic actions of insulin [29,30]. Insulin resistance plays an influential role in the development and persistence of PCOS. This is mainly due to a defect in insulin receptors resulting from excessive serine phosphorylation and decreased tyrosine phosphorylation, which leads to a decrease in insulin activation of the phosphatidylinositol-3-kinase signaling pathway that activates glucose transport and consequently increases glucose levels [31,32]. Increased insulin secretion directly triggers the pi

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